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Estriol

产品号 DB04573 公司名称 DrugBank
CAS号 50-27-1 公司网站 http://www.ualberta.ca/
分子式 C18H24O3 电 话 (780) 492-3111
分子量 288.38136 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 4141

产品价格信息

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产品别名

标题
Estriol
IUPAC标准名
(1S,10R,11S,13R,14R,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,13,14-triol
IUPAC传统名
estriol
商标名
Estriel
Deuslon-A
别名
3,16-alpha,17-beta-Trihydroxy-delta-1,3,5-estratriene
3,16alpha,17beta-Trihydroxy-delta-1,3,5-oestratriene
1,3,5-Estratriene-3beta,16alpha,17beta-triol
Oestriol
(16alpha,17beta)-estra-1,3,5(10)-triene-3,16,17-triol
1,3,5(10)-Estratriene-3,16alpha,17beta-triol
1,3,5-Oestratriene-3beta,16alpha,17beta-triol
16-alpha-Hydroxyoestradiol
16alpha,17beta-Estriol
16alpha-Hydroxyoestradiol
3,16-alpha,17-beta-Oestriol
3,16-alpha,17-beta-Trihydroxyestra-1,3,5(10)-triene
Tridestrin
(16alpha,17beta)-Oestra-1,3,5(10)-triene-3,16,17-triol
16-alpha,17-beta-Estriol
16-alpha,17-beta-Oestriol
16-alpha-Hydroxyestradiol
16alpha,17beta-Oestriol
16alpha-Hydroxy-17beta-estradiol
16alpha-hydroxyestradiol
3,16-alpha,17-beta-Estriol
3,16-alpha,17-beta-Trihydroxy-delta-1,3,5-oestratriene
3,16-alpha,17-beta-Trihydroxyoestra-1,3,5(10)-triene
3,16alpha,17beta-Estriol
3,16alpha,17beta-Trihydroxy-1,3,5(10)-estratriene
3,16alpha,17beta-trihydroxy-Delta(1,3,5)-estratriene
ESL
Estra-1,3,5(10)-trien-3,16alpha,17beta-triol
Estra-1,3,5(10)-triene-3,16,17-triol
Estratriol
Estriolo [italian]
Oestra-1,3,5(10)-triene-3,16alpha,17beta-triol
Oestriolum
Ovestrion
1,3,5(10)-Estratriene-3,16,17-Triol

产品登记号

PubChem SID 46505881
CAS号 50-27-1
PubChem CID 5756

产品性质

疏水性(logP) 2.45 [HANSCH,C ET AL. (1995)]

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes.
Indication Used as a test to determine the general health of an unborn fetus.
Pharmacology Estriol (also oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the placenta. In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.
Toxicity ORAL (LD50): Acute: >2000 mg/kg [Rat].
Affected Organisms
Humans and other mammals
References
Soldan SS, Alvarez Retuerto AI, Sicotte NL, Voskuhl RR: Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol. J Immunol. 2003 Dec 1;171(11):6267-74. [Pubmed]
[Trimesta]
External Links
Wikipedia

参考文献

  • Soldan SS, Alvarez Retuerto AI, Sicotte NL, Voskuhl RR: Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol. J Immunol. 2003 Dec 1;171(11):6267-74. Pubmed
  • Trimesta