Niflumic Acid

• 产品号: DB04552
• CAS号: 4394-00-7
• 分子式: C13H9F3N2O2
• 分子量: 282.2179696

产品别名

• 标题: Niflumic Acid
• IUPAC标准名: 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic acid
• IUPAC传统名: niflumic acid
• 商标名: Forenol; Actol; Flogovital; Niflam; Nifluril; Landruma
• 别名: 2-[3-(Trifluoromethyl)anilino]nicotinic acid; Nifluminic acid; Acido niflumico [inn-spanish]; Acidum niflumicum [inn-latin]; 2-[(3-Trifluoromethyl)Phenyl]Amino-3-Pyridine-Carboxylic Acid; NFL; 2-(alpha,alpha,alpha-Trifluoro-m-toluidino)nicotinic acid; 2-(3-Trifluoromethyl-phenylamino)-nicotinic acid; 2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid; Niflumate; NFA; Lopac-N-0630; Acide niflumique [inn-french]; 2-(3-(Trifluoromethyl)anilino)nicotinic acid

产品登记号

• PubChem SID: 46504657
• CAS号: 4394-00-7
• PubChem CID: 4488

产品性质

• 疏水性(logP): 4.43 [TAKACS-NOVAK,K ET AL. (1995)]
• 溶解度: 0.019 mg/mL at 25 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. [PubChem]
• Indication: Used in the treatment of rheumatoid arthritis.
• Pharmacology: Niflumic acid, a nonsteroidal anti-inflammatory fenamate, is a Ca^2+-activated Cl^- channel blocker.
• Toxicity: Oral, mouse: LD₅₀ = 350 mg/kg; Oral, rat: LD₅₀ = 250 mg/kg
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic.
• Absorption: Well absorbed following oral administration.
• Half Life: 2.5 hours
• Protein Binding: 90% bound to plasma proteins.
• References: Criddle DN, de Moura RS, Greenwood IA, Large WA: Inhibitory action of niflumic acid on noradrenaline- and 5-hydroxytryptamine-induced pressor responses in the isolated mesenteric vascular bed of the rat. Br J Pharmacol. 1997 Mar;120(5):813-8. [Pubmed]

参考文献

• Criddle DN, de Moura RS, Greenwood IA, Large WA: Inhibitory action of niflumic acid on noradrenaline- and 5-hydroxytryptamine-induced pressor responses in the isolated mesenteric vascular bed of the rat. Br J Pharmacol. 1997 Mar;120(5):813-8. Pubmed