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L-Citrulline

产品号 DB00155 公司名称 DrugBank
CAS号 372-75-8 公司网站 http://www.ualberta.ca/
分子式 C6H13N3O3 电 话 (780) 492-3111
分子量 175.18572 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 41

产品价格信息

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产品别名

标题
L-Citrulline
IUPAC标准名
(2S)-2-amino-5-(carbamoylamino)pentanoic acid
IUPAC传统名
L-citrulline
别名
N5-carbamylornithine
N5-(Aminocarbonyl)ornithine
N5-Carbamoyl-L-ornithine
Sitrulline
2-Amino-5-uredovaleric acid
Citrulline
delta-Ureidonorvaline
N5-carbamoylornithine

产品登记号

PubChem CID 9750
PubChem SID 46506583
CAS号 372-75-8

产品性质

疏水性(logP) -3.9
溶解度 200 g/L (at 20 oC)

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved; nutraceutical
Description Citrulline is an amino acid. It is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle. It is also produced from arginine as a by-product of the reaction catalyzed by NOS family. Its name is derived from citrullus, the Latin word for watermelon, from which it was first isolated.
Indication Used for nutritional supplementation, also for treating dietary shortage or imbalance.
Pharmacology A non-essential amino acid and a precursor of arginine. Citrulline supplements have been claimed to promote energy levels, stimulate the immune system and help detoxify ammonia (a cell toxin). L-citrulline is made from L-ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle. It is also produced from L-arginine as a by-product of the reaction catalyzed by the enzyme NO synthase. L-citrulline, while being an amino acid, is not involved in protein synthesis and is not one of the amino acids coded for by DNA. Although citrulline cannot be incorporated in proteins during protein synthesis, several proteins are known to contain citrulline as an amino acid. These citrulline residues are generated by a family of enzymes called peptidylarginine deiminases (PADs), which convert the amino acid arginine into citrulline. Proteins that contain citrulline residues include myelin basic protein (MBP), fillagrin and several histone proteins.
Affected Organisms
Humans and other mammals

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