Zomepirac Acyl-O-β-D-glucuronide

• 产品号: Z675010
• CAS号: 75871-31-7
• 分子式: C21H22ClNO9
• 分子量: 467.85368
• 保 存: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

产品别名

• 标题: Zomepirac Acyl-O-β-D-glucuronide
• IUPAC标准名: (2S,3S,4S,5R,6S)-6-({2-[5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl]acetyl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid
• IUPAC传统名: (2S,3S,4S,5R,6S)-6-({2-[5-(4-chlorobenzoyl)-1,4-dimethylpyrrol-2-yl]acetyl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid
• 别名: Zomepirac Acyl-1-O-β-D-glucuronide; Zomepirac Glucuronide; 1-[5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetate] β-D-Glucopyranuronic Acid

产品登记号

• CAS号: 75871-31-7

产品性质

• 外观: Pale Yellow Solid
• 熔点: >133°C (dec.)
• 溶解度: Methanol
• 保存条件: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

产品详细信息

详细说明 (English)

An unstable metabolite of the nonsteroidal anti-inflammatory drug (NSAID) Zomepirac (Z675000) that is capable of reacting with endogenous proteins to form potentially toxic covalent ZP-protein adducts.

参考文献

• King, A.R. et al.: J. Phamacol. Toxicol. Meth., 36, 131 (1996)
• Olsen, J. et al.: Chem. Res. Toxicol., 18, 1729 (1996)
• O’Neill, P.J. et al.: J. Clin. Pharmacol., 22, 470 (1996)