Zofenopril-d5 Calcium Salt

• 产品号: Z587002
• 分子式: C44H44CaN2O8S4
• 分子量: 897.16676

产品别名

• 标题: Zofenopril-d5 Calcium Salt
• IUPAC标准名: calcium bis((2R,4S)-1-[(2S)-3-(benzoylsulfanyl)-2-methylpropanoyl]-4-[(^2H₅)phenylsulfanyl]pyrrolidine-2-carboxylate)
• IUPAC传统名: calcium bis((2R,4S)-1-[(2S)-3-(benzoylsulfanyl)-2-methylpropanoyl]-4-[(^2H₅)phenylsulfanyl]pyrrolidine-2-carboxylate)
• 别名: Zofenil-d5; Bifril-d5; [1(S),4(S)]-1-(3-Mercapto-2-methyl-1-oxopropyl)-4-phenyl-thio-L-proline-S-benzoyl-d5 Ester Calcium Salt

产品性质

• 外观: Off-White to Light Yellow Crystalline Solid
• 熔点: >250°C

产品详细信息

详细说明 (English)

Angiotensin-converting enzyme ACE inhibitor. A prodrug that is de-esterified to the active inhibitor, the sulfhydryl group containing metabolite, Zofenoprilat.

参考文献

• Gorren, A., et al.: Biochem. J., 331, 801 (1998)
• Subissi, A., et al.: Cardivascular Drug Reviews, 17, 2 (1998)
• Marchand, C., et al.: Mol. Pharmacol., 64, 600 (1998)
• Maurin, C., et al.: J. Med. Chem., 47, 5583 (1998)