ZM 213689 (Meropenem impurity)(Mixture of double bond isomers)

• 产品号: Z486500
• 分子式: C34H54N6O12S2
• 分子量: 802.95556

产品别名

• 标题: ZM 213689 (Meropenem impurity)(Mixture of double bond isomers)
• IUPAC标准名: (3R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid; (4R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
• IUPAC传统名: (3S,4R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-3H-pyrrole-2-carboxylic acid; (4R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
• 别名: H 4295; (αS,2S,3R,4S)-5-Carboxy-4-[[(3S,5S)-5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-3,4-dihydro-α-[(1R)-hydroxyethyl]-3-methyl-2H-pyrrole-2-acetic Acid; UK 1a; ICI 213689

产品详细信息

详细说明 (English)

The major metabolite of Meropenem (M225620) - a carbapenem antibiotic - in plasma and urine. This metabolite existed as a mixture of 1-pyrroline and its 2-pyrroline isomer, and the coexistence of the two isomers at equilibrium in aqueous solutions was obs

参考文献

• Takeuchi, Y., et al.: J. Antibiotics, 46, 827 (1993)
• Wiseman, L., et al.: Drugs, 50, 73 (1993)
• Valtonen, M., et al.: J. Antimicrob. Chemother., 45, 701 (1993)