XL518

• 产品号: X746250
• CAS号: 934660-93-2
• 分子式: C21H21F3IN3O2
• 分子量: 531.3100196

产品别名

• 标题: XL518
• IUPAC标准名: 1-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl}-3-[(2S)-piperidin-2-yl]azetidin-3-ol
• IUPAC传统名: 1-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl}-3-[(2S)-piperidin-2-yl]azetidin-3-ol
• 别名: GDC 0973; XL 518; [3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl][3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl]methanone

产品登记号

• CAS号: 934660-93-2

产品详细信息

详细说明 (English)

A potent, selective, orally bioavailable inhibitor of MEK1, a component of the RAS/RAF/MEK/ERK pathway. It inhibits proliferation and stimulates apoptosis in a variety of human tumor cell lines. In preclinical xenograft models, oral administration of XL51

参考文献

• Rosen, L.S. et al.: J. Clin. Oncol., 26, 14585 (2008)