XAV 939

• 产品号: X744000
• CAS号: 284028-89-3
• 分子式: C14H11F3N2OS
• 分子量: 312.3101496

产品别名

• 标题: XAV 939
• IUPAC标准名: 2-[4-(trifluoromethyl)phenyl]-1H,4H,5H,7H,8H-thiopyrano[4,3-d]pyrimidin-4-one
• IUPAC传统名: 2-[4-(trifluoromethyl)phenyl]-1H,5H,7H,8H-thiopyrano[4,3-d]pyrimidin-4-one
• 别名: NVP-XAV 939; 1,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one

产品登记号

• CAS号: 284028-89-3

产品详细信息

详细说明 (English)

A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.

参考文献

• Huang, S. et al.: Nature, 461, 614 (2009)
• Wang, H. et al.: ACS Chem. Biol., 6, 192 (2009)
• Adles, M.E. et al.: Sci. Signal., 91, ec326 (2009)