VX 745

• 产品号: V900500
• CAS号: 209410-46-8
• 分子式: C19H9Cl2F2N3OS
• 分子量: 436.2620664

产品别名

• 标题: VX 745
• IUPAC标准名: 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one
• IUPAC传统名: 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]pyrimido[1,6-b]pyridazin-6-one
• 别名: 5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one

产品登记号

• CAS号: 209410-46-8

产品详细信息

详细说明 (English)

VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome.

参考文献

• Haddad, J.J.: Curr. Opin. Invest. Drugs, 2, 1070 (2001)
• Duffy, J.P. et al.: ACS Med. Chem. Lett., 2, 758 (2001)
• Bagley, M.C. et al.: Pharmaceuticals, 3, 1842 (2001)