Vandetanib-d4

• 产品号: V097102
• 分子式: C22H24BrFN4O2
• 分子量: 475.3539632

产品别名

• 标题: Vandetanib-d4
• IUPAC标准名: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-{[1-methyl(2,2,6,6-^2H₄)piperidin-4-yl]methoxy}quinazolin-4-amine
• IUPAC传统名: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-{[1-methyl(2,2,6,6-^2H₄)piperidin-4-yl]methoxy}quinazolin-4-amine
• 别名: 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[[1-methyl(piperidin-4-yl)-d4]methoxy]quinazoline; Zactima-d4; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[[1-methyl-4-(piperidinyl-d4)]methoxy]-4-quinazolinamine; ZD 6474-d4

产品详细信息

详细说明 (English)

A labelled Vandetanib; a once-daily oral inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor kinase activity. The activity of vandetanib plus docetaxel was assessed in patients with previously treated non-small-

参考文献

• Bruns, C., et al.: Clin. Cancer Res., 6, 1936 (2000)
• Hennequin, L., et al.: J. Med. Chem., 45, 1300 (2000)
• Park, M., et al.: J. Biol. Chem., 278, 50624 (2000)
• Arao, T., et al.: Cancer Res., 64, 9101 (2000)
• Prueitt, R., et al.: Int. J. Cancer, 120, 796