N-Trifluoroacetyl-N-methyl-deacetylcolchicine

• 产品号: T789510
• CAS号: 71295-35-7
• 分子式: C23H24F3NO6
• 分子量: 467.4349696

产品别名

• 标题: N-Trifluoroacetyl-N-methyl-deacetylcolchicine
• IUPAC标准名: 2,2,2-trifluoro-N-methyl-N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl]acetamide
• IUPAC传统名: 2,2,2-trifluoro-N-methyl-N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl]acetamide
• 别名: N-(Trifluoroacetyl)demecolchine; N-Trifluoroacetyldemecolcine; NSC 317022; (S)-2,2,2-Trifluoro-N-methyl-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide

产品登记号

• CAS号: 71295-35-7

产品性质

• 外观: Yellow Solid
• 溶解度: Chloromethane
• 溶解度: Dichlormethane
• 溶解度: DMSO
• 溶解度: Methanol

产品详细信息

详细说明 (English)

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pa

参考文献

• Andreu, J.M., et al.: Biochemistry, 37, 8356 (1992)
• Jordan, A., et al.: Med. Res. Rev
• Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992)
• Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1992)
• Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1992)