(3S,6R,7S,8S,12Z,15S,16E)-1,3,15-Tris-{[tert-butyl(dimethyl)silyl]oxy}-7-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)heptadecyl-12,16-dien-5-one

• 产品号: T876675
• CAS号: 193146-49-5
• 分子式: C45H87NO5SSi3
• 分子量: 838.49748

产品别名

• 标题: (3S,6R,7S,8S,12Z,15S,16E)-1,3,15-Tris-{[tert-butyl(dimethyl)silyl]oxy}-7-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)heptadecyl-12,16-dien-5-one
• IUPAC标准名: (7S,11S,12S,16Z,19S)-7-[(tert-butyldimethylsilyl)oxy]-11-hydroxy-2,2,3,3,8,8,10,12,16,21,21,22,22-tridecamethyl-19-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,20-dioxa-3,21-disilatricos-16-en-9-one
• IUPAC传统名: (7S,11S,12S,16Z,19S)-7-[(tert-butyldimethylsilyl)oxy]-11-hydroxy-2,2,3,3,8,8,10,12,16,21,21,22,22-tridecamethyl-19-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,20-dioxa-3,21-disilatricos-16-en-9-one

产品登记号

• CAS号: 193146-49-5

产品性质

• 外观: Colourless Oil
• 溶解度: Acetone
• 溶解度: Chloroform
• 溶解度: Dichloromethane
• 溶解度: Ethanol
• 溶解度: Ethyl Acetate
• 溶解度: Hexane
• 溶解度: Methanol

产品详细信息

详细说明 (English)

An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical

参考文献

• Hoee, G., et al.: Pure Appl. Chem., 71, 11, 2019 (1999)
• Giannakakou, P., et al.: Proc. Natl. Acad. Sci. USA, 97, 2904 (2000)