Triciribine

• 产品号: T774245
• CAS号: 35943-35-2
• 分子式: C13H16N6O4
• 分子量: 320.30394

产品别名

• 标题: Triciribine
• IUPAC标准名: (2R,4R,5R)-2-{5-amino-7-methyl-2,6,7,9,11-pentaazatricyclo[6.3.1.0^4,^1^2]dodeca-1(11),3,5,8(12),9-pentaen-2-yl}-5-(hydroxymethyl)oxolane-3,4-diol
• IUPAC传统名: (2R,4R,5R)-2-{5-amino-7-methyl-2,6,7,9,11-pentaazatricyclo[6.3.1.0^4,^1^2]dodeca-1(11),3,5,8(12),9-pentaen-2-yl}-5-(hydroxymethyl)oxolane-3,4-diol
• 别名: NSC 154020; TCN; API 2; 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine; 6-Amino-4-methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine

产品登记号

• CAS号: 35943-35-2

产品详细信息

详细说明 (English)

Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including

参考文献

• Garrett, C.R. et al.: Invest. New Drugs, 29, 1381 (2011)
• Ptak, R.G. et al.: AIDS Res. Human Retrovir., 14, 1315 (2011)
• Bennett, L.L. et al.: BIochem. Pharmacol., 27, 233 (2011)