Trabectedin

• 产品号: T703500
• CAS号: 114899-77-3
• 分子式: C39H43N3O11S
• 分子量: 761.83722

产品别名

• 标题: Trabectedin
• IUPAC标准名: (1R,12S,14R)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'H-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1^3,^1^1.0^2,^1^3.0^4,^9.0^1^5,^2^3.0^1^6,^2^0]triacontane-26,1'-isoquinoline]-4(9),5,7,15,20,22-hexaen-22-yl acetate
• IUPAC传统名: (1R,12S,14R)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'H-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1^3,^1^1.0^2,^1^3.0^4,^9.0^1^5,^2^3.0^1^6,^2^0]triacontane-26,1'-isoquinoline]-4(9),5,7,15,20,22-hexaen-22-yl acetate
• 别名: (1'R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinolin]-19-one; Ecteinascidin 743; Et 743; NSC 648766; Yondelis

产品登记号

• CAS号: 114899-77-3

产品详细信息

详细说明 (English)

A tetrahydroisoquinoline alkaloid with antitumor activity isolated from the Caribbean tunicate, Ecteinascidin turbinata. It is the first marine anticancer agent approved in the European Union for patients with soft tissue sarcoma (STS). Antineoplastic.

参考文献

• Sakai, R., et al.: Proc. Natl. Acad. Sci., 89, 11456 (1992)
• Aune, G., et al.: Anticancer Drugs, 13, 545 (1992)
• Herrero, A., et al.: Cancer Res., 66, 8155 (1992)
• Sugasawa, K., et al.: Carcinogenesis, 29, 455 (1992)