Thiamet GDiscontinued

• 产品号: T344155
• CAS号: 1009816-48-1
• 分子式: C9H16N2O4S
• 分子量: 248.29934

产品别名

• 标题: Thiamet GDiscontinued
• IUPAC标准名: (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-3aH,5H,6H,7H,7aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
• IUPAC传统名: (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-3aH,5H,6H,7H,7aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
• 别名: (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol

产品登记号

• CAS号: 1009816-48-1

产品详细信息

详细说明 (English)

A potent O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. The authors anticipate that Thiamet-G will find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological hype

参考文献

• Chou, T., et al.: J. Biol. Chem., 270, 18961 (1995)
• Cheng, X., et al.; Biochemistry, 39, 11609 (1995)
• Farook, V., et al.: Mol. Genet. Metab., 77, 189 (1995)
• Lefebvre, T., et al.: Biochim. Biophys. Acta, 1619, 167 (1995)
• Cho, J., et al.: J. Neurochem.,