SN-38 Carboxylate Disodium Salt

• 产品号: S589960
• 分子式: C22H20N2Na2O6
• 分子量: 454.38354
• 保 存: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

产品别名

• 标题: SN-38 Carboxylate Disodium Salt
• IUPAC标准名: disodium (2S)-2-[12-ethyl-8-(hydroxymethyl)-2-oxido-9-oxo-9H,11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoate
• IUPAC传统名: disodium (2S)-2-[12-ethyl-8-(hydroxymethyl)-2-oxido-9-oxo-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoate
• 别名: SN 38 Acid Sodium Salt; (αS)-α,12-Diethyl-9,11-dihydro-α,2-dihydroxy-8-(hydroxymethyl)-9-oxo-9-indolizino[1,2-b]quinoline-7-acetic Acid Disodium Salt

产品性质

• 外观: Yellow Solid
• 熔点: >220°C (dec.)
• 溶解度: DMSO
• 溶解度: Methanol
• 溶解度: Water
• 保存条件: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

产品详细信息

详细说明 (English)

The active metabolite of Irinotecan (carboxylate form). SN-38 lactone and carboxylate may be considered pharmacokinetically distinct agents.

参考文献

• Billecke, S., et al.: Drug Metab. Dispos., 28, 1335 (2000)
• Teiber, J., et al.: Biochem. Pharmacol., 66, 887 (2000)
• Ashley, G., et al.: J. Antibiot., 57, 224 (2000)