Simvastatin

• 产品号: S485000
• CAS号: 79902-63-9
• 分子式: C25H38O5
• 分子量: 418.56622
• 保 存: -20°C Freezer, Under Inert Atmosphere

产品别名

• 标题: Simvastatin
• IUPAC标准名: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
• IUPAC传统名: simvastatin
• 别名: (+)-Simvastatin; 2,2-Dimethylbutanoic Acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester; Simvotin; Lipex; Statin; Zocor; Cholestat; Novo-Simvastatin; Sinvacor; Zorced

产品登记号

• CAS号: 79902-63-9

产品性质

• 外观: White Powder
• 熔点: 123-125°C
• 溶解度: Dichloromethane
• 溶解度: Ether
• 溶解度: Ethyl Acetate
• 溶解度: Methanol
• 保存条件: -20°C Freezer, Under Inert Atmosphere

产品详细信息

详细说明 (English)

Simvastatin is a synthetic derivate of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.

参考文献

• Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986)
• Mol, M.J., et al.: Lancet, 2, 936 (1986)