Saxagliptin-13C3

• 产品号: S143502
• 分子式: C18H25N3O2
• 分子量: 318.38796451

产品别名

• 标题: Saxagliptin-13C3
• IUPAC标准名: (1R,3R,5S)-2-[(2S)-2-amino-2-[(1r,3R,5R,7S)-3-hydroxyadamantan-1-yl](1,2-^1^3C₂)acetyl](6-^1^3C)-2-azabicyclo[3.1.0]hexane-3-carbonitrile
• IUPAC传统名: (1R,3R,5S)-2-[(2S)-2-amino-2-[(1r,3R,5R,7S)-3-hydroxyadamantan-1-yl](1,2-^1^3C₂)acetyl](6-^1^3C)-2-azabicyclo[3.1.0]hexane-3-carbonitrile
• 别名: (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile-13C3; BMS 477118-13C3; Onglyza-13C3; BMS 477118-11-13C3

产品详细信息

详细说明 (English)

Labelled Saxagliptin. It is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible

参考文献

• Feng, J., et al.: J. Med. Chem., 50, 2297 (2007)
• Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2007)
• Thomas, L., et al.: J. Pharmacol. Exp. Ther., 325, 175 (2007)