rac-Ruxolitinib-d8

• 产品号: R701998
• 分子式: C17H18N6
• 分子量: 306.36502

产品别名

• 标题: rac-Ruxolitinib-d8
• IUPAC标准名: 3-[(2,2,3,3,4,4,5,5-^2H₈)cyclopentyl]-3-(4-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazol-1-yl)propanenitrile
• IUPAC传统名: 3-[(2,2,3,3,4,4,5,5-^2H₈)cyclopentyl]-3-(4-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}pyrazol-1-yl)propanenitrile
• 别名: β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile; INCB 018424-d8

产品详细信息

详细说明 (English)

Labelled racemic analogue of Ruxolitinib (R702000). Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis.

参考文献

• Shilling, A.D. et al.: Drug Metab. Disp., 38, 2023 (2010)
• Mesa, R.A.: IDrugs, 13, 394 (2010)
• Campas-Moya, C.: Drugs Fut., 35, 457 (2010)