(5R)-Rupintrivir

• 产品号: R701690
• 分子式: C31H39FN4O7
• 分子量: 598.6623632
• 保 存: -20°C Freezer, Under Inert Atmosphere

产品别名

• 标题: (5R)-Rupintrivir
• IUPAC标准名: ethyl (2E,4S)-4-[(2R,5R)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[(5-methyl-1,2-oxazol-3-yl)formamido]-4-oxoheptanamido]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate
• IUPAC传统名: ethyl (2E,4S)-4-[(2R,5R)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[(5-methyl-1,2-oxazol-3-yl)formamido]-4-oxoheptanamido]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate
• 别名: (2E,4S)-4-[[(2R,5R)-2-[(4-Fluorophenyl)methyl]-6-methyl-5-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-1,4-dioxoheptyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid

产品性质

• 外观: Off-white solid
• 熔点: 138-140°C
• 溶解度: Chloroform
• 溶解度: Methanol
• 保存条件: -20°C Freezer, Under Inert Atmosphere

产品详细信息

详细说明 (English)

The 5R-enantiomer of Rupintrivir (R701700). Rupintrivir (formerly AG7088) is an irreversible inhibitor of the human rhinovirus (HRV) 3C protease that has been demonstrated to have in vitro activity against all HRVs tested, consistent with its interaction

参考文献

• Arruda, E., et al.: J. Clin. Microbiol., 35, 2864 ( 1997), Dragovich, P., et al.: J. Med. Chem., 42, 1213 (1999)
• Kaiser, L., et al.: Antivir. Res., 47, 215 (1999)
• Binford, S., et al.: Antimicrob. Agents Chemother., 49, 619 (1999)
• Schmidtke, M., et al.: