Romidepsin-d8

• 产品号: R425062
• 分子式: C24H36N4O6S2
• 分子量: 540.69584

产品别名

• 标题: Romidepsin-d8
• IUPAC标准名: (1S,4S,7Z,16E,21R)-7-ethylidene-21-(propan-2-yl)-4-[(^2H₇)propan-2-yl](4-^2H)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
• IUPAC传统名: (1S,4S,7Z,16E,21R)-7-ethylidene-21-isopropyl-4-[(^2H₇)propan-2-yl](4-^2H)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
• 别名: [S-(E)]-N-(3-Hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3-didehydro-2-aminobutanoyl-L-valine (4-1)-Lactone-d8 Cyclic (12)-Disulfide; Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl]-d8 Cyclic (35)-Disulfide; FR 901228-d8; Chromadax-d8; Antibiotic FR 901228-d8; FK 228-d8; NSC 630176-d8

产品详细信息

详细说明 (English)

Labelled Romidepsin (R425060). Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibi

参考文献

• Ueda, H., et al.: J. Antibiot., 47, 301 (1994)
• Weidle, U., et al.: Anticancer Res., 20, 1471 (1994)
• Kitazono, M., et al.: Cancer Res., 61, 6328 (1994)
• Sandor, V., et al.: Clin. Cancer Res., 8, 718 (1994)