Resatorvid

• 产品号: R144570
• CAS号: 243984-11-4
• 分子式: C15H17ClFNO4S
• 分子量: 361.8161832

产品别名

• 标题: Resatorvid
• IUPAC标准名: ethyl (6S)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate
• IUPAC传统名: ethyl (6S)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate
• 别名: (6R)-6-[[(2-Chloro-4-fluorophenyl)amino]sulfonyl]-1-cyclohexene-1-carboxylic Acid Ethyl Ester; TAK 242

产品登记号

• CAS号: 243984-11-4

产品详细信息

详细说明 (English)

Resatorvid is a novel selective Toll-like receptor 4 signal transduction inhibitor. Resatorvid inhibits various kinds of inflammatory mediators such as nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, IL-10, macrophage inhibitor

参考文献

• Abraham, E., et al.: Lancet, 351, 929 (1998)
• Akashi, S., et al.: J. Exp. Med., 198, 1035 (1998)
• Akira, S., et al.: Immunol. Lett., 85, 85 (1998)
• Medvedev, A., et al.: J. Biol. Chem., 282, 16042 (1998)