Pracinostat-d7

• 产品号: P699102
• 分子式: C20H30N4O2
• 分子量: 358.4778

产品别名

• 标题: Pracinostat-d7
• IUPAC标准名: (2E)-3-{2-[(2,2,3,3,4,4,4-^2H₇)butyl]-1-[2-(diethylamino)ethyl]-1H-1,3-benzodiazol-5-yl}-N-hydroxyprop-2-enamide
• IUPAC传统名: (2E)-3-{2-[(2,2,3,3,4,4,4-^2H₇)butyl]-1-[2-(diethylamino)ethyl]-1,3-benzodiazol-5-yl}-N-hydroxyprop-2-enamide
• 别名: Kaempferol 3-O-β-D-(6-E-p-Coumaroylglucoside)-d7; (2E)-3-[2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-2-propenamide-d7; SB939-d7; (E)-3-[2-Butyl-1-(2-diethylaminoethyl)-1H-benzimidazol-5-yl]-N-hydroxy-2-propenamide-d7; (2E)-3-[2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxyacrylamide-d7; SB 939-d7

产品详细信息

详细说明 (English)

Labelled Pracinostat. Pracinostat is a potent and orally active histone deacetylase (HDAC) inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. The selectivity of Pracinostat for tumor tissues makes it a promising therapeu

参考文献

• Novotny-Diermayr, V. et al.: Mol. Cancer Therap., 9, 642 (2010)
• Razak, A.R.A. et al.: Br. J. Cancer, 104, 756 (2010)
• Novotny-Diermayr, V. et al.: Mol. Cancer Therap., 10, 1207 (2010)