Plazomicin

• 产品号: P579500
• CAS号: 1154757-24-0
• 分子式: C25H48N6O10
• 分子量: 592.68282

产品别名

• 标题: Plazomicin
• IUPAC标准名: (2S)-4-amino-N-[(1R,2S,5S)-5-amino-4-{[(2S)-3-amino-6-{[(2-hydroxyethyl)amino]methyl}-3,4-dihydro-2H-pyran-2-yl]oxy}-2-{[(2R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide
• IUPAC传统名: (2S)-4-amino-N-[(1R,2S,5S)-5-amino-4-{[(2S)-3-amino-6-{[(2-hydroxyethyl)amino]methyl}-3,4-dihydro-2H-pyran-2-yl]oxy}-2-{[(2R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide
• 别名: ACHN 490; O-2-Amino-2,3,4,6-tetradeoxy-6-[(2-hydroxyethyl)amino]-α-D-glycero-hex-4-enopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine

产品登记号

• CAS号: 1154757-24-0

产品详细信息

详细说明 (English)

Plazomicin is a neoglycoside antibiotic with activity against a broad range of Gram-positive and Gram-negive pathogens. Plazomicin showed potent in vitro activity against multidrug-resistant Klebsiella pneumoniae and Escherichia coli.

参考文献

• Endimiani, A. et al.: Antimicrob. Agents Chemother., 53, 4504 (2009)
• Landman, D. et al.: J. Antimicrob. Chemother., 65, 2123 (2009)
• Landman, D. et al.: J. Antimicrob. Chemother., 66, 332 (2009)