Pitavastatin-d5 Lactone

• 产品号: P531022
• 分子式: C25H22FNO3
• 分子量: 403.4454832
• 保 存: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

产品别名

• 标题: Pitavastatin-d5 Lactone
• IUPAC标准名: (4R,6S)-6-[(E)-2-[2-(^2H₅)cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]ethenyl]-4-hydroxyoxan-2-one
• IUPAC传统名: (4R,6S)-6-[(E)-2-[2-(^2H₅)cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]ethenyl]-4-hydroxyoxan-2-one
• 别名: NK 104-d5 (lactone); [4R-[4α,6β(E)]]-6-[2-[2-(Cyclopropyl-d5)-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one; (4R,6S)-6-[(1E)-2-[2-(Cyclopropyl-d5)-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one; P 872441-d5; NK 104-d5; Nisvastatin-d5

产品性质

• 外观: Off-White to Pale Yellow Solid
• 熔点: 72-75°C
• 溶解度: Chloroform
• 溶解度: Ethyl Acetate
• 保存条件: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

产品详细信息

详细说明 (English)

A labelled metabolite of Pitavastatin. Recent studies have shown that conversion between acid and lactone forms occurs in the body, drug-drug interaction should be considered on both acid and lactone forms. The inhibitory effects of statins on CYP metabol

参考文献

• Wang, J., et al.: Drug Metab. Dispos., 30, 1352 (2002)
• Yamada, I., et al.: Xenobiotica, 33, 789 (2002)
• Fujino, H., et al.: Xenobiotica, 34, 961 (2002)
• Ando, H., et al.: Br. J. Clin. Pharmacol., 60, 494 (2002)