(1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate

• 产品号: P458530
• CAS号: 205393-22-2
• 分子式: C29H39BN4O4
• 分子量: 518.45536
• 保 存: -20°C Freezer

产品别名

• 标题: (1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate
• IUPAC标准名: (2S)-N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.0^2,^6]decan-4-yl]butyl]-3-phenyl-2-(pyrazin-2-ylformamido)propanamide
• IUPAC传统名: (2S)-N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.0^2,^6]decan-4-yl]butyl]-3-phenyl-2-(pyrazin-2-ylformamido)propanamide
• 别名: N-[(1S)-2-[[(1R)-1-[(3aS,4S,6S,7aR)-Hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide

产品登记号

• CAS号: 205393-22-2

产品性质

• 外观: Yellow Solid
• 熔点: 75-83°C
• 溶解度: Chloroform
• 溶解度: Dimethyl Sulfoxide
• 溶解度: Ethanol
• 溶解度: Ethyl Acetate
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

Intermediate in the preparation of Bortezomib (B675700), a dipeptidyl boronate proteasome inhibitor.

参考文献

• Zhu, Y., et al.: Bioorg. Med. Chem., 14, 1483 (2006)
• Dorsey, B., et al.: J. Med. Chem., 51, 1068 (2006)
• Zhu, Y., et al.: Eur. J .Med. Chem., 44, 1486 (2006)