Pimozide-d5

• 产品号: P447802
• 分子式: C28H29F2N3O
• 分子量: 461.5461664

产品别名

• 标题: Pimozide-d5
• IUPAC标准名: 1-{1-[4,4-bis(4-fluorophenyl)butyl](3,3,4,5,5-^2H₅)piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
• IUPAC传统名: 1-{1-[4,4-bis(4-fluorophenyl)butyl](3,3,4,5,5-^2H₅)piperidin-4-yl}-3H-1,3-benzodiazol-2-one
• 别名: 1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one-d5; NSC 170984-d5; R 6238-d5; 1-[1-[4,4-Bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone-d5; 1-[4,4-Bis(p-fluorophenyl)butyl]-4-(2-oxo-1-benzimidazolinyl)piperidine-d5; Orap-d5; Primozide-d5

产品详细信息

详细说明 (English)

Labelled analogue of Pimozide, a D2 dopamine receptor antagonist. Pimozide binds with high affinity to the cloned 5-HT7 receptor. Pimozide is also a Ca2+ channel antagonist. Pimozide is used as an antipsychotic.

参考文献

• Liu, J., et al.: Br. J. Pharmacol., 126, 245 (1999)
• Richelson, E., et al.: Life Sci., 68, 29 (1999)
• Santi, C., et al.: J. Neurosci., 22, 396 (1999)
• Mariot, P., et al.: J. Biol. Chem., 277, 10824 (1999)
• Nikonenko, I., et al.: Mol. Pharmacol., 68, 84 (2