PF 04217903 Mesylate

• 产品号: P293990
• CAS号: 956906-93-7
• 分子式: C20H20N8O4S
• 分子量: 468.489

产品别名

• 标题: PF 04217903 Mesylate
• IUPAC标准名: 2-{4-[1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl}ethan-1-ol; methanesulfonic acid
• IUPAC传统名: 2-{4-[3-(quinolin-6-ylmethyl)-[1,2,3]triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl}ethanol; methanesulfonic acid
• 别名: 4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol Methanesulfonate

产品登记号

• CAS号: 956906-93-7

产品详细信息

详细说明 (English)

PF 04217903 is highly selective, high affinity c-Met inhibitor (Ki = 6-7 nM against wild type c-Met). Displays >1000-fold selectivity for c-Met over a panel of 208 kinases.

参考文献

• Eder, et al.: Clin. Cancer Res., 15, 2207 (2009)
• Timofeevski, et al.: Biochemistry, 48, 5339 (2009)
• Underiner, et al.: Anticancer Agents Med.Chem., 10, 7 (2009)