PD-173074-d9

• 产品号: P217702
• 分子式: C28H41N7O3
• 分子量: 523.67024
• 保 存: Refrigerator

产品别名

• 标题: PD-173074-d9
• IUPAC标准名: 1-(2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-[2-(^2H₃)methyl(^2H₆)propan-2-yl]urea
• IUPAC传统名: 1-(2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-[2-(^2H₃)methyl(^2H₆)propan-2-yl]urea
• 别名: PD 173074-d9; N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl-d9)urea

产品性质

• 外观: Yellow Solid
• 熔点: 83-85°C
• 溶解度: Chloroform
• 溶解度: Methanol
• 保存条件: Refrigerator

产品详细信息

详细说明 (English)

Labelled PD 173074 (P217700). A selective FGFR1 and FGFR3 inhibitor. The compound induced a dose-dependent reduce in cell viability and an increase in apoptosis, accompanied by a decrease in extracellular signal-related kinase phosphorylation.

参考文献

• Mohammadi, M., et al.: Science, 276, 955 (1997)
• Yagasaki, F., et al.: Cancer Res., 61, 8371 (1997)
• Keats, J., et al.: Blood, 101, 1520 (1997)
• Buchler, et al.: 9, 119 (1997)