PD-149163

• 产品号: P217480
• CAS号: 169528-11-4
• 分子式: C42H71N9O6
• 分子量: 798.06984

产品别名

• 标题: PD-149163
• IUPAC标准名: ethyl (2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-6-amino-2-{[(2S)-2,6-diaminohexyl]amino}hexanoyl]pyrrolidin-2-yl]formamido}-3-(1H-indol-3-yl)propanamido]-3,3-dimethylbutanamido]-4-methylpentanoate
• IUPAC传统名: ethyl (2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-6-amino-2-{[(2S)-2,6-diaminohexyl]amino}hexanoyl]pyrrolidin-2-yl]formamido}-3-(1H-indol-3-yl)propanamido]-3,3-dimethylbutanamido]-4-methylpentanoate
• 别名: (S)-N-[N-[N-[1-[N2-(2,6-Diaminohexyl)-L-lysyl]-L-prolyl]-L-tryptophyl]-3-methyl-L-valyl]-L-leucine Ethyl Ester; PF-01472472; N2-[(2S)-2,6-Diaminohexyl]-L-lysyl-L-prolyl-L-tryptophyl-3-methyl-L-valyl-L-leucine Ethyl Ester

产品登记号

• CAS号: 169528-11-4

产品详细信息

详细说明 (English)

PD 149163 is a selective, brain penetrating Neurotensin NTR1 receptor agonist. Neurotensin agonists such as PD 149163 block the prepulse inhibition deficits produced by a 5-HT2A and an α1 agonist. As a result, PD 149163 shows pro-cognitive, antipsychotic

参考文献

• Feifel, D. et al.: Neuropsychophamacology, 28, 651 (2003)
• Shilling, P.D. et al.: Psychopharmacolgy, 175, 353 (2003)