(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

• 产品号: O865000
• CAS号: 767340-03-4
• 分子式: C16H13F6N5O
• 分子量: 405.2977392
• 保 存: Refrigerator

产品别名

• 标题: (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine
• IUPAC标准名: (2Z)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)but-2-en-1-one
• IUPAC传统名: (2Z)-3-amino-1-[3-(trifluoromethyl)-5H,6H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)but-2-en-1-one
• 别名: (2Z)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one; 2,3-Desdihydrogen rac-Sitagliptin

产品登记号

• CAS号: 767340-03-4

产品性质

• 外观: White Solid
• 熔点: 178-180°C
• 溶解度: DMSO
• 溶解度: Methanol
• 保存条件: Refrigerator

产品详细信息

详细说明 (English)

Sitagliptin intermediate. A dipeptidyl peptidase-4 inhibitor and an anti-hypertensive agent for the treatment of diabetes and hypertension.

参考文献

• Kim, D., et al.: J. Med. Chem., 48, 141 (2005)
• Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005)
• Bergman, A., et al: Clin. Ther., 28, 55 (2006)