Otamixaban

• 产品号: O712500
• CAS号: 193153-04-7
• 分子式: C25H26N4O4
• 分子量: 446.49834

产品别名

• 标题: Otamixaban
• IUPAC标准名: 4-(4-{[(2R,3R)-3-[(3-carbamimidoylphenyl)methyl]-4-methoxy-4-oxobutan-2-yl]carbamoyl}phenyl)pyridin-1-ium-1-olate
• IUPAC传统名: otamixaban
• 别名: Methyl (2R,3R)-2-[3-Amidinobenzyl]-3-[[4-(1-oxido-4-pyridinyl)benzoyl]amino]butanoate; (αR)-3-(Aminoiminomethyl)-α-[(1R)-1-[[4-(1-oxido-4-pyridinyl)benzoyl]amino]ethyl]benzenepropanoic Acid Methyl Ester; FXV 673; [R-(R*,R*)]-3-(Aminoiminomethyl)-α-[1-[[4-(1-oxido-4-pyridinyl)benzoyl]amino]ethyl]benzenepropanoic Acid Methyl Ester

产品登记号

• CAS号: 193153-04-7

产品详细信息

详细说明 (English)

A potent (Ki = 0.5 nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa. Clinical studies show that it is efficacious, safe and well tolerated in humans and therefore has c

参考文献

• Guertin, K.R. et al.: Curr. Med. Chem., 14, 2471 (2007)
• Hinder, M. et al.: Clin. Pharmacol. Therap., 80, 691 (2007)
• Hinder, M. et al.: Thromb. Haemost., 95, 224 (2007)