S-(4-Nitrobenzyl)-6-thioinosine

• 产品号: N493695
• CAS号: 38048-32-7
• 分子式: C17H17N5O6S
• 分子量: 419.41178
• 保 存: Refrigerator

产品别名

• 标题: S-(4-Nitrobenzyl)-6-thioinosine
• IUPAC标准名: (2S,3R,4S,5S)-2-(hydroxymethyl)-5-(6-{[(4-nitrophenyl)methyl]sulfanyl}-9H-purin-9-yl)oxolane-3,4-diol
• IUPAC传统名: (2S,3R,4S,5S)-2-(hydroxymethyl)-5-(6-{[(4-nitrophenyl)methyl]sulfanyl}purin-9-yl)oxolane-3,4-diol
• 别名: NSC 296962; 6-S-[(4-Nitrophenyl)methyl]-6-thioinosine; S-(p-Nitrobenzyl)-6-mercapto-9-β-D-ribofuranosylpurine; NBMPR; 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine

产品登记号

• CAS号: 38048-32-7

产品性质

• 外观: Off-White Solid
• 熔点: 177-180°C
• 溶解度: DMSO
• 溶解度: Ethyl Acetate
• 保存条件: Refrigerator

产品详细信息

详细说明 (English)

It is a prototype inhibitor of the human equilibrative nucleoside transporter (hENT1), and is a high affinity ligand with a Kd of 0.1-1.0 nM. Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardioprotect

参考文献

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• Zhu, Z., et al.: J. Med. Chem., 46, 831 (1989)
• Baldwin, S., et al.: J. Biol. Chem., 280, 15880 (1989)
• Barnes, K., et al.: Circ. Res., 99, 510 (2006