Nimbolide

• 产品号: N476300
• CAS号: 25990-37-8
• 分子式: C27H30O7
• 分子量: 466.5229
• 保 存: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

产品别名

• 标题: Nimbolide
• IUPAC标准名: methyl 2-[6-(furan-3-yl)-7,9,11,15-tetramethyl-12,16-dioxo-3,17-dioxapentacyclo[9.6.1.0^2,^9.0^4,^8.0^1^5,^1^8]octadeca-7,13-dien-10-yl]acetate
• IUPAC传统名: methyl 2-[6-(furan-3-yl)-7,9,11,15-tetramethyl-12,16-dioxo-3,17-dioxapentacyclo[9.6.1.0^2,^9.0^4,^8.0^1^5,^1^8]octadeca-7,13-dien-10-yl]acetate
• 别名: NSC 309909; (4α,5α,6α,7α,15β,17α)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Αcid γ-lactone Methyl Ester

产品登记号

• CAS号: 25990-37-8

产品性质

• 外观: Light Beige Solid
• 熔点: >223°C (dec.)
• 溶解度: Chloroform
• 溶解度: Ethyl Acetate
• 保存条件: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

产品详细信息

详细说明 (English)

Nimbolide, a natural triterpenoid present in the edible parts of the neem tree (Azadirachta indica), was found to be growth-inhibitory in human colon carcinoma HT-29 cells. Nimbolide treatment of cells at 2.5 - 10 μM resulted in moderate to very strong gr

参考文献

• Khalid, S., et al.: J. Nat. Prod., 52, 922 (1989)
• Cohen, E., et al.: J. Life Sci., 58, 1075 (1989)
• Moragoda, L., et al.: Anticancer Res., 21, 873 (1989)
• Chang, K., et al.: Biochem. Pharmacol., 67, 717 (1989)
• Parsels, L., et al.: Cancer Res., 64, 6588