Nalfurafine Hydrochloride

• 产品号: N255600
• CAS号: 152658-17-8
• 分子式: C28H33ClN2O5
• 分子量: 513.02502
• 保 存: Controlled Substance, -20°C Freezer

产品别名

• 标题: Nalfurafine Hydrochloride
• IUPAC标准名: (2E)-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^1,^1^3.0^5,^1^7.0^7,^1^8]octadeca-7(18),8,10-trien-14-yl]-3-(furan-3-yl)-N-methylprop-2-enamide hydrochloride
• IUPAC传统名: (2E)-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^1,^1^3.0^5,^1^7.0^7,^1^8]octadeca-7(18),8,10-trien-14-yl]-3-(furan-3-yl)-N-methylprop-2-enamide hydrochloride
• 别名: (-)-17-(Cyclopropylmethyl)-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan Hydrochloride; (2E)-N-[(5α,6β)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-2-propenamide Hydrochloride; TRK 820; Remitch

产品登记号

• CAS号: 152658-17-8

产品性质

• 保存条件: Controlled Substance, -20°C Freezer

产品详细信息

详细说明 (English)

Nalfurafine hydrochloride was launched on March of 2009 in Japan as the first in class non-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rat

参考文献

• Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004)
• Mori, T., et al.: Life Sci., 75, 2433 (2004)
• Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2004)
• Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2004)