MLN 4924

• 产品号: M425100
• CAS号: 905579-51-3
• 分子式: C21H25N5O4S
• 分子量: 443.5193
• 保 存: -20°C Freezer

产品别名

• 标题: MLN 4924
• IUPAC标准名: [(1S,2R,4R)-4-(4-{[(1S)-2,3-dihydro-1H-inden-1-yl]amino}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl]methyl sulfamate
• IUPAC传统名: [(1S,2R,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate
• 别名: Sulfamic Acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl Ester

产品登记号

• CAS号: 905579-51-3

产品性质

• 外观: White Solid
• 熔点: 148-150°C
• 溶解度: Methanol
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

A potent and selective inhibitor of NAE. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. The ubiquitin-proteasome pathway mediates the destruction of unwanted proteins.

参考文献

• Haas, A., et al.: J. Biol. Chem., 257, 10329 (1982)
• Walden, H., et al.: Nature, 422, 330 (1982)
• Kane, R., et al.: Clin. Cancer Res., 13, 5291 (1982)
• Saha, A., et al.: Mol. Cell., 32, 21 (1982)