MK-2206 Dihydrochloride

• 产品号: M425025
• CAS号: 1032350-13-2
• 分子式: C25H21N5O
• 分子量: 407.46714

产品别名

• 标题: MK-2206 Dihydrochloride
• IUPAC标准名: 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H,3H-[1,2,4]triazolo[3,4-f]1,6-naphthyridin-3-one
• IUPAC传统名: 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f]1,6-naphthyridin-3-one
• 别名: 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one Hydrochloride

产品登记号

• CAS号: 1032350-13-2

产品详细信息

详细说明 (English)

AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vivo and leads to increased survival rates in mice bearin

参考文献

• Yeh, T., et al.: Clin. Cancer Res., 13, 1576 (2007)
• Meng, J., et al.: Cancer Biol. Ther., 8, 2073 (2007)