α-Methyl-γ-hydroxy-1,N2-propano-2'-deoxyguanosine-13C,15N2(Mixture of Diastereomers)

• 产品号: M312892
• 分子式: C14H19N5O5
• 分子量: 340.31063263
• 保 存: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

产品别名

• 标题: α-Methyl-γ-hydroxy-1,N2-propano-2'-deoxyguanosine-13C,15N2(Mixture of Diastereomers)
• IUPAC标准名: 8-hydroxy-3-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-methyl(4a-^1^3C,5,9-^1^5N₂)-3H,5H,6H,7H,8H,10H-pyrimido[1,2-a]purin-10-one
• IUPAC传统名: 8-hydroxy-3-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-methyl(4a-^1^3C,5,9-^1^5N₂)-5H,6H,7H,8H-pyrimido[1,2-a]purin-10-one
• 别名: α-Me-γ-OH-PdG-13C,15N2; Cr-PdG-13C,15N2; 3-(2-Deoxy-β-D-erythro-pentofuranosyl)-4,6,7,8-tetrahydro-8-hydroxy-6-methylpyrimido[1,2-a]purin-10(3H)-one-13C,15N2

产品性质

• 外观: Pale Yellow Solid
• 熔点: 149-152°C
• 溶解度: DMSO
• 溶解度: Methanol
• 保存条件: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

产品详细信息

详细说明 (English)

A genotoxic labelled cyclic adduct of 2'-deoxyguanosine with crotonaldehyde. Histones accelerate the cyclic 1,N2-propanoguanine adduct-formation of DNA by the primary metabolite of alcohol and carcinogenic crotonaldehyde.

参考文献

• Fang, J., et al.: Carcinogenesis, 18, 627 (1997)
• Wang, M., et al.: Chem. Res. Toxicol., 14, 1025 (1997)
• Kurtz, A., et al.: J. Biol. Chem., 278, 5970 (1997)