3-O-Methyl-L-DOPA Monohydrate

• 产品号: M303815
• CAS号: 200630-46-2
• 分子式: C10H15NO5
• 分子量: 229.2298
• 保 存: Hygroscopic, Refrigerator, Under Inert Atmosphere

产品别名

• 标题: 3-O-Methyl-L-DOPA Monohydrate
• IUPAC标准名: (2S)-2-amino-3-(4-hydroxy-3-methoxyphenyl)propanoic acid hydrate
• IUPAC传统名: 3-methoxytyrosine hydrate
• 别名: 3-Methoxy-4-hydroxyphenylalanine Monohydrate; L-3-Methoxy-4-hydroxyphenylalanine Monohydrate; L-3-O-Methyl-DOPA Monohydrate; L-4-Hydroxy-3-methoxyphenylalanine Monohydrate; 3-O-Methyldopa Monohydrate; 3-Methoxy-L-tyrosine Monohydrate; 3-Methoxy-DOPA Monohydrate

产品登记号

• CAS号: 200630-46-2

产品性质

• 外观: Pale Brown Solid
• 熔点: 223-225°C (dec.)
• 溶解度: DMSO
• 溶解度: Methanol
• 保存条件: Hygroscopic, Refrigerator, Under Inert Atmosphere

产品详细信息

详细说明 (English)

3-O-Methyl-L-DOPA is the major metabolite of L-DOPA via catechol O-methyltransferase (COMT). 3-Methoxy-L-tyrosine is neither a substrate for nor an inhibitor of L-amino acid decarboxylase activity. Inhibition of COMT enhances the anti-Parkinson activity o

参考文献

• Soares-da Silva, P., et al.: Brain Res., 863, 293 (2000)
• Deleu, D., et al.: Clin. Pharmacokinet., 41, 261 (2000)