12-O-Methyl Clarithromycin

• 产品号: M294630
• CAS号: 128940-83-0
• 分子式: C39H71NO13
• 分子量: 761.97994

产品别名

• 标题: 12-O-Methyl Clarithromycin
• IUPAC标准名: (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-12-hydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-7,13-dimethoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione
• IUPAC传统名: (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-12-hydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-7,13-dimethoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione
• 别名: 6,12-Di-O-methylerythromycin A; 6,12-Di-O-methylerythromycin; Clarithromycin EP Impurity F

产品登记号

• CAS号: 128940-83-0

产品详细信息

详细说明 (English)

12-O-Methyl Clarithromycin is a methylated impurity of the semi-synthetic macrolide antibiotic Clarithromycin (C559750). 12-O-Methyl Clarithromycin was shown to inhibit uptake of Clarithromycin into the lung cells.

参考文献

• Chen, X. et al.: Zhong. Yao., 17, 32 (2008)
• Yoshida, H. et al.: Jap. J. Antibiot., 53, 615 (2008)
• Omura, S. et al.: Yakug. Zas., 112, 593 (2008)