LY 2228820-d9

• 产品号: L486502
• 分子式: C25H33FN6
• 分子量: 436.5681232

产品别名

• 标题: LY 2228820-d9
• IUPAC标准名: 3-(2,2-dimethylpropyl)-5-[4-(4-fluorophenyl)-2-[2-(^2H₃)methyl(^2H₆)propan-2-yl]-1H-imidazol-5-yl]-3H-imidazo[4,5-b]pyridin-2-amine; methane
• IUPAC传统名: 3-(2,2-dimethylpropyl)-5-[5-(4-fluorophenyl)-2-[2-(^2H₃)methyl(^2H₆)propan-2-yl]-3H-imidazol-4-yl]imidazo[4,5-b]pyridin-2-amine; methane
• 别名: 5-[2-(1,1-Dimethylethyl-d9)-5-(4-fluorophenyl)-1H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine Dimethanesulfonate

产品详细信息

详细说明 (English)

Laballed LY2228820, a novel and potent p38MAPK inhibitor with potent antiinflammatory activity. LY2228820 significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMS

参考文献

• Zhao, R. et al.: Drug Metab. Disp., 37, 1251 (2009)
• Ishitsuka, K. et al.: Br. J. Haematol., 141, 598 (2009)
• Mader, M. et al.: Bioorg. Med. Chem. Lett., 18, 179 (2009)