LY 2228820

• 产品号: L486500
• CAS号: 862507-23-1
• 分子式: C25H33FN6
• 分子量: 436.5681232

产品别名

• 标题: LY 2228820
• IUPAC标准名: 5-[2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine; methane
• IUPAC传统名: 5-[2-tert-butyl-5-(4-fluorophenyl)-3H-imidazol-4-yl]-3-(2,2-dimethylpropyl)imidazo[4,5-b]pyridin-2-amine; methane
• 别名: 5-[2-(1,1-Dimethylethyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine Dimethanesulfonate

产品登记号

• CAS号: 862507-23-1

产品详细信息

详细说明 (English)

LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity. LY2228820 significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY2

参考文献

• Zhao, R. et al.: Drug Metab. Disp., 37, 1251 (2009)
• Ishitsuka, K. et al.: Br. J. Haematol., 141, 598 (2009)
• Mader, M. et al.: Bioorg. Med. Chem. Lett., 18, 179 (2009)