Lometrexol

• 产品号: L469465
• CAS号: 106400-81-1
• 分子式: C21H25N5O6
• 分子量: 443.4531

产品别名

• 标题: Lometrexol
• IUPAC标准名: (2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-4H,4aH,5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-6-yl]ethyl}phenyl)formamido]pentanedioic acid
• IUPAC传统名: (2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-4aH,5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-6-yl]ethyl}phenyl)formamido]pentanedioic acid
• 别名: N-[4-[2-[(6R)-2-Amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-L-glutamic Acid; LY 264618

产品登记号

• CAS号: 106400-81-1

产品详细信息

详细说明 (English)

It is an antifolate which inhibits glycinamide ribonucleotide formyltransferase (GARFT), an enzyme essential for de novo purine synthesis. Lometrexol has activity against tumors which are refractory to other drugs, notably Methotrexate.

参考文献

• Gibbs, D., et al.: Cancer Res., 65, 11721 (2005)
• Gangjee, A., et al.: J. Med. Chem., 48, 5329 (2005)
• Hilgenbrink, A., et al.: J. Pharm. Sci., 94, 2135 (2005)