Larotaxel

• 产品号: L176000
• CAS号: 156294-36-9
• 分子式: C45H53NO14
• 分子量: 831.90062
• 保 存: -20°C Freezer

产品别名

• 标题: Larotaxel
• IUPAC标准名: (1S,2S,3R,4S,7R,9S,11R,13S,16S)-4,13-bis(acetyloxy)-16-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-15,18,18-trimethyl-12-oxo-6-oxapentacyclo[12.3.1.0^3,^1^1.0^4,^7.0^9,^1^1]octadec-14-en-2-yl benzoate
• IUPAC传统名: (1S,2S,3R,4S,7R,9S,11R,13S,16S)-4,13-bis(acetyloxy)-16-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-15,18,18-trimethyl-12-oxo-6-oxapentacyclo[12.3.1.0^3,^1^1.0^4,^7.0^9,^1^1]octadec-14-en-2-yl benzoate
• 别名: PNU 100940; (αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic Acid (1S,2S,4S,7R,8aR,9aS,10aR,12aS,12bR)-7,12a-Bis(acetyloxy)-1-(benzoyloxy)-1,3,4,7,8,9,9a,10,10a,12,12a,12b-dodecahydro-2-hydroxy-5,13,13-trimethyl-8-oxo-2,6-methano-2H-cyclodeca[3,4]cyclopropa[4,5]benz[1,2-b]oxet-4-yl Ester

产品登记号

• CAS号: 156294-36-9

产品性质

• 外观: White Solid
• 熔点: 180-182°C
• 溶解度: Chloroform
• 溶解度: Methanol
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

Larotaxel (RPR 109881A) is a taxane analog with a broad spectrum of activity and different toxicity profile and with the possible advantages of surpassing some mechanisms of resistance and penetrating into the CNS.

参考文献

• Kurata, T., et al.: J. Clin. Oncol., 18, 3164 (2000)
• Kemper, E., et al.: Eur. J. Cancer, 40, 1269 (2000)
• Nyman, D., et al.: J. Clin. Oncol., 23, 7785 (2000)