KU-0058948

• 产品号: K660400
• CAS号: 763111-49-5
• 分子式: C21H21FN4O2
• 分子量: 380.4154432

产品别名

• 标题: KU-0058948
• IUPAC标准名: 4-{[3-(1,4-diazepane-1-carbonyl)-4-fluorophenyl]methyl}-1,2-dihydrophthalazin-1-one
• IUPAC传统名: 4-{[3-(1,4-diazepane-1-carbonyl)-4-fluorophenyl]methyl}-2H-phthalazin-1-one
• 别名: KU0058948; 4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone; KU 0058948; 1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine

产品登记号

• CAS号: 763111-49-5

产品详细信息

详细说明 (English)

KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary

参考文献

• Klevernic, I.V. et al.: FEBS Lett., 583, 680 (2009)
• Gaymes, T.J. et al.: Haematologica, 94, 638 (2009)