3-Keto-N-aminoethyl-N'-aminocaproyldihydrocinnamoyl Cyclopamine, >80%

• 产品号: K171000
• CAS号: 306387-90-6
• 分子式: C44H63N3O4
• 分子量: 697.98872
• 保 存: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

产品别名

• 标题: 3-Keto-N-aminoethyl-N'-aminocaproyldihydrocinnamoyl Cyclopamine, >80%
• IUPAC标准名: N-{2-[(3'R,7'aR)-3',6',10,11b-tetramethyl-3-oxo-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3'H-spiro[cyclohexa[a]fluorene-9,2'-furo[3,2-b]pyridine]-4'-yl]ethyl}-6-(3-phenylpropanamido)hexanamide
• IUPAC传统名: N-{2-[(3'R,7'aR)-3',6',10,11b-tetramethyl-3-oxo-1,2,3',3'a,4,5',6,6',6a,6b,7,7',7'a,8,11,11a-hexadecahydrospiro[cyclohexa[a]fluorene-9,2'-furo[3,2-b]pyridine]-4'-yl]ethyl}-6-(3-phenylpropanamido)hexanamide
• 别名: KAAD-Cyclopamine

产品登记号

• CAS号: 306387-90-6

产品性质

• 外观: Pale Yellow Solid
• 溶解度: Chloroform
• 溶解度: Methanol
• 保存条件: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

产品详细信息

详细说明 (English)

Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects ofoncogenic mutations in Smoothened and Patched.1 The KAAD-Cyclopamine has shown 10-20 fold higher potency than cyclopamine in inhibition of β-Galactosidase expression in p2Ptch-1- cells, with similar or lower toxicity. KAAD-Cyclopamine compound is unstable in solution.

参考文献

• Taipale, J., et al.: Nature, 406, 1005 (2000)
• Perron, M., et al.: Development, 130, 1565 (2000)