Kenpaullone

• 产品号: K162500
• CAS号: 142273-20-9
• 分子式: C16H11BrN2O
• 分子量: 327.17534
• 保 存: -20°C Freezer

产品别名

• 标题: Kenpaullone
• IUPAC标准名: 14-bromo-8,18-diazatetracyclo[9.7.0.0^2,^7.0^1^2,^1^7]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
• IUPAC传统名: 14-bromo-8,18-diazatetracyclo[9.7.0.0^2,^7.0^1^2,^1^7]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
• 别名: 9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one; 9-Bromopaullone; NSC 664704

产品登记号

• CAS号: 142273-20-9

产品性质

• 外观: Dark Yellow Solid
• 熔点: >300°C (dec.)
• 溶解度: DMSO
• 溶解度: Ethyl Acetate
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

The paullones are a novel class of kinase inhibitors, initially identified as CDK inhibitors. Kenpaullone has been found to be a useful GSK-3β inhibitor (IC50=23nM).

参考文献

• Zaharevitz, D.W., et al.: Cancer Res., 59, 2566 (1999)
• Leclerc, S., et al.: J. Biol. Chem., 276, 251 (1999)
• Bain, J., et al.: Biochem. J., in press.