5-Iodomethyl 6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy)-androsta-1,4-diene-17β-carbothioate

• 产品号: I709000
• CAS号: 80474-67-5
• 分子式: C25H31F2IO5S
• 分子量: 608.4769164

产品别名

• 标题: 5-Iodomethyl 6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy)-androsta-1,4-diene-17β-carbothioate
• IUPAC标准名: (1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-17-hydroxy-14-{[(iodomethyl)sulfanyl]carbonyl}-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,6-dien-14-yl propanoate
• IUPAC传统名: (1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-17-hydroxy-14-{[(iodomethyl)sulfanyl]carbonyl}-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,6-dien-14-yl propanoate
• 别名: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-androsta-1,4-diene-17-carbothioic Acid S-(Iodomethyl) Ester

产品登记号

• CAS号: 80474-67-5

产品性质

• 外观: Off-White Solid
• 溶解度: Chloroform
• 溶解度: Dichloromethane
• 溶解度: DMF
• 溶解度: Ethanol
• 溶解度: Ethyl Acetate
• 溶解度: Methanol

产品详细信息

详细说明 (English)

An intermediate in the synthesis of Fluticasone Propionate.

参考文献

• Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990)
• Mitchison, H.C., et al.: Gut, 32, 260 (1990)
• Phillipps, G.H., et al.: J. Med. Chem., 37, 3717 (1994)