Ilepatril

• 产品号: I266500
• CAS号: 473289-62-2
• 分子式: C22H28N2O5S
• 分子量: 432.53312

产品别名

• 标题: Ilepatril
• IUPAC标准名: (2R,6R,9S)-9-[(2S)-2-(acetylsulfanyl)-3-methylbutanamido]-8-oxo-7-azatricyclo[9.4.0.0^2,^7]pentadeca-1(11),12,14-triene-6-carboxylic acid
• IUPAC传统名: (2R,6R,9S)-9-[(2S)-2-(acetylsulfanyl)-3-methylbutanamido]-8-oxo-7-azatricyclo[9.4.0.0^2,^7]pentadeca-1(11),12,14-triene-6-carboxylic acid
• 别名: AVE-7688; (4S,7S,12bR)-7-[[(2S)-2-(Acetylthio)-3-methyl-1-oxobutyl]amino]-1,2,3,4,6,7,8,12b-octahydro-6-oxo-pyrido[2,1-a][2]benzazepine-4-carboxylic Acid

产品登记号

• CAS号: 473289-62-2

产品详细信息

详细说明 (English)

A dual angiotensin-converting enzyme and neutral endopeptidase inhibitor, for the potential treatment of hypertension and diabetic nephropathy. Ilepatril is currently in phase IIb/III clinical trials for hypertension and phase II trials for diabetic nephr

参考文献

• Tabrizchi, R., et al.: Drugs, 63, 2185 (2003)
• Azizi, M., et al.: Clin. Pharmacol. Ther., 79 49 (2003)
• Davidson, E., et al.: Diabetes, 56, 355 (2003)
• Del Colle, S., et al.: J. Cardiovasc. Pharmacol., 50, 487 (2003)