iCRT-14

• 产品号: I163900
• CAS号: 677331-12-3
• 分子式: C21H17N3O2S
• 分子量: 375.44358

产品别名

• 标题: iCRT-14
• IUPAC标准名: (5Z)-5-{[2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl]methylidene}-3-phenyl-1,3-thiazolidine-2,4-dione
• IUPAC传统名: (5Z)-5-{[2,5-dimethyl-1-(pyridin-3-yl)pyrrol-3-yl]methylidene}-3-phenyl-1,3-thiazolidine-2,4-dione
• 别名: iCRT 14; iCRT14; 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione

产品登记号

• CAS号: 677331-12-3

产品详细信息

详细说明 (English)

A potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between β-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-

参考文献

• Gonsalves, F.C. et al.: Proc. Natl. Acad. Sci. USA, 108, 5954 (2011)
• Watanabe, K. et al.: Proc. Natl. Acad. Sci. USA, 108, 5929 (2011)